Ancient DNA reveals plague was already killing humans 5,500 years ago

Plague was already a deadly killer 5,500 years ago, long before cities, farming, or the rat-infested conditions usually linked to historic outbreaks. By analyzing ancient DNA from hunter-gatherer cemeteries in Siberia, researchers discovered early plague strains in nearly 40% of the individuals studied and found evidence of rapid family-based outbreaks that wiped out many children and young teenagers.

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A surprising discovery reveals the kidney has a secret backup system

Scientists at Mayo Clinic have uncovered a surprising new way the kidneys conserve water, revealing a hidden backup system that works independently of the hormone long believed to control the process. The discovery emerged when researchers testing an old drug called probenecid expected it to worsen polycystic kidney disease (PKD) but found it actually slowed cyst growth instead.

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Common plastic chemical linked to lifelong anxiety in new study

Exposure to a common plastic chemical before and shortly after birth may have lasting effects on behavior. Researchers found that male rats exposed early in life to DEHP—a plasticizer used in products ranging from medical devices to toys—showed significantly higher anxiety as adults, even long after exposure had ended. The animals were more hesitant to explore open spaces and spent more time frozen in place, classic signs of anxiety in rodents.

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Scientists say most of what’s in your food is still a mystery

Scientists are beginning to explore a hidden world of thousands of food chemicals that go far beyond the nutrients listed on nutrition labels. This “nutritional dark matter” may hold the key to understanding disease risk, healthy aging, and why different diets affect people in dramatically different ways.

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Your brain was never designed for this much bad news

Humans evolved to pay close attention to danger, but today that instinct is being overwhelmed by an endless supply of bad news from around the world. Researchers say the answer isn’t to stop following current events—it’s to build healthier habits around how, when, and where we get our news.

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New GLP-1 diabetes pill delivers major weight loss and blood sugar control

A new oral GLP-1 medication helped people with type 2 diabetes dramatically improve blood sugar control and lose weight in a major clinical trial. The results suggest that highly effective diabetes treatments may soon become available in a much more convenient pill form.

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Reversing prediabetes cuts risk of deadly heart problems by 58%

Bringing blood sugar levels back to normal may dramatically reduce the danger posed by prediabetes. Researchers found that people who reversed prediabetes cut their risk of cardiovascular death or hospitalization for heart failure by 58% and lowered their chances of major heart problems such as heart attacks and strokes by 42%. The benefits lasted for decades and were seen across large long-term studies in both the U.S. and China.

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Why middle age is becoming a breaking point in the U.S.

A new international study finds that middle-aged Americans are lonelier, more depressed, and experiencing worse memory and health than earlier generations. Researchers say growing financial strain, weaker social supports, and chronic stress may explain why the U.S. is falling behind other wealthy nations.

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New fentanyl vaccine blocks deadly overdoses before they start

A new experimental vaccine developed by Scripps Research could offer a powerful new way to prevent fentanyl overdoses by stopping the drug before it reaches the brain. Rather than targeting only fentanyl itself, the vaccine trains the immune system to recognize a broad range of fentanyl-related designer drugs, including some of the most dangerous variants.

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Stanford scientists regrow lost cartilage and reverse arthritis in major breakthrough

A new treatment that blocks an aging-related protein restored lost cartilage in old mice and helped prevent arthritis after knee injuries. Human cartilage samples showed similar signs of regeneration, raising hopes for a future drug that could repair joints instead of replacing them.

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