Aging muscles may be losing strength for a reason scientists missed

A newly identified breakdown in communication between nerves and muscles could help explain why people lose strength as they age. Researchers were able to improve muscle strength in an animal model by targeting a key protein, raising hopes that some age-related weakness could eventually be treated.

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Rare pregnancy infections may triple the risk of autism

A major Swedish study of 3.7 million people has found that rare TORCH infections passed from a pregnant woman to the fetus are linked to much higher risks of autism and intellectual disability later in life. Children with a congenital TORCH infection were about three times more likely to be diagnosed with autism, more than seven times more likely to have an intellectual disability, and up to 30 times more likely to have severe to profound intellectual disability.

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This new drug could break cancer’s resistance to treatment

A new experimental drug called CS18 may help break through cancer drug resistance by disabling several of the defenses tumors use to survive treatment. It strengthened existing therapies, restored drug sensitivity in resistant lung cancer cells, and slowed tumor growth in animal models.

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Coffee doesn’t have to keep you awake to disrupt your sleep

Caffeine may make sleep less restorative even when you fall asleep normally and stay in bed for eight hours, with EEG recordings revealing fewer of the slow brain waves associated with deep sleep. Individual sensitivity varies dramatically, meaning even caffeine consumed earlier in the day could affect nighttime recovery for some people.

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Stanford scientists discover the human brain may actually be two separate organs

Scientists have found that the human brain develops from two distinct cellular systems, suggesting that evolution fused together two ancient nervous systems with very different jobs. The discovery also allowed researchers to grow human hindbrain neurons in the lab, opening new possibilities for studying ALS, spinal muscular atrophy, and other brainstem diseases.

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Millions take calcium and vitamin D for bone health. A major review finds little benefit

A sweeping review of more than 153,000 adults found that calcium and vitamin D supplements, alone or together, do little to prevent fractures or falls in most older people. Researchers say the findings challenge routine supplementation for prevention and point instead toward strategies such as balance and resistance exercise.

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Ancient DNA reveals how plague kept returning for 400 years after the Black Death

Ancient DNA reveals that plague repeatedly returned to Europe for more than 400 years after the Black Death, evolving into new lineages and spreading through trade, migration, and war. Researchers also developed a method to date ancient plague genomes more precisely, linking many of them to specific outbreaks recorded in historical sources.

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Hidden gut defect that may explain why IBD keeps coming back

Researchers have uncovered a hidden molecular warning sign of inflammatory bowel disease (IBD) that can linger even when patients feel well and appear to be in remission. By studying around 900 human gut biopsies and patient-derived mini-intestines, the team found that intestinal cells can remain unusually primed to die, creating a “smoldering” defect that may help drive future flare-ups.

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Scientists discover cells that cheat death and rebuild damaged tissue

Scientists discovered a population of cells that can start the process of programmed cell death, survive it, and then help rapidly rebuild damaged tissue. Their descendants become far more resistant to future damage, revealing a mechanism that could improve healing but may also help cancers return after treatment.

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Ozempic can change your body. Can it change your life?

Ozempic and other GLP-1 medications can improve blood sugar, weight, and cardiovascular health, but researchers found little evidence that they also improve mental health, employment, marriage, or overall well-being. The findings suggest the drugs’ broader life effects may be subtler than their dramatic physical health benefits.

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