Viagra and shingles vaccine show surprising promise against Alzheimer’s

A major new study has spotlighted three familiar medicines that could take on an unexpected new role in the fight against Alzheimer’s disease — with a shingles vaccine emerging as the front-runner. After reviewing 80 existing drugs, an international panel of experts identified Zostavax, Viagra (sildenafil), and riluzole as the most promising candidates for repurposing.

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Breakthrough CRISPR system could reverse antibiotic resistance crisis

Antibiotic resistance is racing toward a global crisis, with “superbugs” projected to cause over 10 million deaths annually by 2050. Now, scientists at UC San Diego have unveiled a powerful new CRISPR-based tool that doesn’t just fight resistant bacteria—it can actively strip away their drug resistance. Inspired by gene drives used in insects, the technology spreads a genetic “fix” through bacterial populations, even inside stubborn biofilms that shield microbes from antibiotics.

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One stem cell generates 14 million tumor-killing NK cells in major cancer breakthrough

Scientists in China have unveiled a breakthrough way to mass-produce powerful cancer-fighting immune cells in the lab. By engineering early-stage stem cells from cord blood—rather than trying to modify mature natural killer (NK) cells—they created a streamlined process that generates enormous numbers of highly potent NK cells, including CAR-equipped versions designed to hunt specific cancers.

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Scientists discover brain switches that clear Alzheimer’s plaques

Researchers have identified two brain receptors that help the brain clear away amyloid beta, a hallmark of Alzheimer’s disease. By stimulating these receptors in mice, scientists increased levels of a natural amyloid-breaking enzyme, reduced buildup in the brain, and improved memory-related behavior. Because these receptors are common drug targets, the findings could open the door to affordable pill-based treatments with fewer side effects.

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Lab grown human spinal cord heals after injury in major breakthrough

Researchers have built a realistic human mini spinal cord in the lab and used it to simulate traumatic injury. The model reproduced key damage seen in real spinal cord injuries, including inflammation and scar formation. After treatment with fast moving “dancing molecules,” nerve fibers began growing again and scar tissue shrank. The results suggest the therapy could eventually help repair spinal cord damage.

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Brain inflammation may be driving compulsive behavior

For years, compulsive behaviors have been viewed as bad habits stuck on autopilot. But new research in rats found the opposite: inflammation in a key decision-making brain region actually made behavior more deliberate, not more automatic. The change was linked to astrocytes, brain support cells that multiplied and disrupted nearby circuits. The discovery hints that some compulsive behaviors may arise from excessive, misdirected control rather than a loss of it.

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One in three people carry this brain parasite but the body has a kill switch

A parasite that may already be hiding in your brain has a shocking survival trick: it can infect the very immune cells sent to destroy it. Yet most people never get sick, and new research from UVA Health reveals why. Scientists discovered that when Toxoplasma gondii invades CD8+ T cells — key defenders of the immune system — those cells can trigger a self-destruct mechanism powered by an enzyme called caspase-8. By sacrificing themselves, the infected cells also wipe out the parasite inside them.

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Exercise may be one of the most powerful treatments for depression and anxiety

A sweeping review of global research suggests that exercise—especially aerobic activities like running, swimming, and dancing—can be one of the most powerful ways to ease depression and anxiety. Across tens of thousands of people aged 10 to 90, exercise consistently reduced symptoms, often matching or even outperforming medication and talk therapy.

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Scientists find nerves actively fuel pancreatic cancer

Scientists have uncovered a hidden partnership between pancreatic cancer and the nervous system. Support cells in the pancreas lure nerve fibers, which then release signals that accelerate early cancer growth. This creates a self-sustaining loop that helps tumors take hold. Blocking the nerve activity significantly reduced tumor growth in experiments, suggesting a new treatment strategy.

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Psychedelics may work by shutting down reality and unlocking memory

Psychedelics can quiet the brain’s visual input system, pushing it to replace missing details with vivid fragments from memory. Scientists found that slow, rhythmic brain waves help shift perception away from the outside world and toward internal recall — almost like dreaming while awake. By imaging glowing brain cells in mice, researchers watched this process unfold in real time.

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