Physical signals as fate deciders: How mechanical forces extrude cells from tissues

Epithelial tissues are in constant interaction with their environment. Maintaining their functionality requires dynamic balance (homeostasis) and that their cell numbers are tightly regulated. This is achieved by cell extrusion programs, a checkpoint mechanism eliminating unwanted or harmful cells. Researchers have now demonstrated how physical signals can have an impact on the fate of extruding cells governing their death or survival. The results may establish novel paths for understanding tissue properties in both normal and pathological conditions.

from Top Health News -- ScienceDaily https://ift.tt/arqFE5K